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HLAB27 supports the work-up of joint pain, stiffness and swelling and helps in the early diagnosis of inflammatory arthritis.
Also known as: HLA-B27
Sample
Blood
Fasting
Not required
Report in
24 hours
Collection
Free at home
HLA-B27 is a genetic marker test that detects a specific protein on the surface of white blood cells, strongly associated with a group of inflammatory conditions affecting the spine and joints, most notably ankylosing spondylitis.
Ordered to help support the diagnosis of ankylosing spondylitis or related inflammatory joint conditions, especially in people with chronic lower back pain and stiffness that started before age 40.
It can help your doctor assess
Ankylosing spondylitis and related conditions (collectively called spondyloarthritis), when combined with the clinical picture.
This test may be considered for:
Whether this test is right for you depends on your symptoms, medical history and the reason for testing - your doctor can advise.
The presence or absence of the HLA-B27 genetic marker.
HLA-B27
Genetic Marker
A genetic marker - it doesn’t change over time and is present in a significant proportion of people with ankylosing spondylitis, though also in some people without any disease.
How to read your result
Your report should be read using the reference interval, unit and method shown by the performing laboratory. A result outside a reference interval does not automatically establish a diagnosis, and a result inside the interval does not rule out every health problem. Clinical interpretation depends on symptoms, history and other findings.
| Marker | Result | What it may be associated with |
|---|---|---|
| HLA-B27 | Positive | Supports a diagnosis of ankylosing spondylitis or related inflammatory joint disease when combined with typical symptoms - not diagnostic on its own since some HLA-B27-positive people never develop disease. |
If a result is outside the range
If the HLAB27 is reported as high, low, positive, negative or otherwise outside the laboratory's stated interval, the meaning depends on the specific test and the reason it was ordered. Your clinician may consider repeat testing, related investigations or other clinical information before deciding what the result means.
Limitations of this test
A positive HLA-B27 doesn’t confirm disease - many people carry this gene without ever developing symptoms, so it’s only meaningful alongside a suggestive clinical picture.
An abnormal result does not by itself mean you have a particular disease. Your doctor interprets results together with your symptoms, history and other tests.
| Parameter | Reference range | Unit |
|---|---|---|
| HLA-B27 | Negative | — |
Typical adult ranges for guidance. Reference intervals vary with the laboratory method, age and sex - always read your result against the range printed on your own report.
Book
Choose the test and a time slot online, or call us and we'll book it for you.
Prepare
Follow the preparation steps above for this test.
Sample collection
A trained phlebotomist collects the sample at your home - no extra charge.
Laboratory processing
Your sample is processed in our laboratory and reviewed by a pathologist.
Report
Your report is shared on WhatsApp and email, usually within 24 hours.
For a blood-based test, a small blood sample is collected by a trained healthcare professional, usually from a vein in the arm. The collection normally takes only a few minutes; mild temporary discomfort or bruising can occur at the puncture site.
This is a genetic test, so the result doesn’t change with diet, medicines, or timing - it’s tested once rather than repeated.
Laboratory results are interpreted together with your symptoms, medical history and other investigations. If your results are significantly abnormal, or you have symptoms that worry you, discuss them with a qualified doctor promptly.
Trusted public health sources for the information on this page:
This information is for general awareness and does not replace advice from your doctor.
The HLAB27 test cost in Mumbai at HWP Diagnostic is ₹1,349 - 23% less than the MRP of ₹1,749. There are no extra charges for home sample collection. The same price applies across Malad, Kandivali, Borivali and Goregaon.
| Test | HLAB27 |
|---|---|
| Price at HWP Diagnostic | ₹1,349 |
| MRP | ₹1,749 (you save ₹400 - 23% off) |
| Home collection charge | Free |
| Report time | 24 hours |
| Fasting | Not required |
| Available in | Malad, Kandivali, Borivali & Goregaon (same price) |
Book the HLAB27 test with free home sample collection anywhere in Malad, Kandivali, Borivali and Goregaon, or walk in to our lab in Malad West, Mumbai - open 24×7.
Home collection areas include
Malad WestMalwani & KharodiMalad EastKandivali WestKandivali EastBorivali WestGorai & Borivali WestIC Colony & MandapeshwarBorivali EastGoregaon WestBangur Nagar & Motilal NagarGoregaon EastAarey ColonyDahisarJogeshwari WestJogeshwari East
Directions on Google MapsIt is also known as HLA-B27.
Home collection at the same price (₹1,349) across these areas, with our lab in Malad West open 24×7.
Get this test along with other important checks - usually for less than booking them separately.
No fasting is required.
Not necessarily - many people carry this gene without ever developing the condition. It’s used to support a diagnosis alongside your symptoms and other clinical findings, not as a standalone diagnostic test.
Yes, since HLA-B27 is a genetic marker that doesn’t change over your lifetime, there’s no need to repeat this test once you’ve had a result.
HLAB27 is a blood test. HLAB27 supports the work-up of joint pain, stiffness and swelling and helps in the early diagnosis of inflammatory arthritis.
The HLAB27 may be ordered when a healthcare professional needs information about the condition or health area assessed by this test. HLAB27 supports the work-up of joint pain, stiffness and swelling and helps in the early diagnosis of inflammatory arthritis. At HWP Diagnostic the sample can be collected free at your home in Malad and nearby Mumbai areas, and the report is usually shared within the same day or next day. Please carry or upload your doctor's prescription where the test needs one, and discuss the result with your doctor for a full interpretation.
HLAB27 supports the work-up of joint pain, stiffness and swelling and helps in the early diagnosis of inflammatory arthritis.
The test may be relevant for people whose symptoms, medical history, screening needs or treatment monitoring match the purpose of the HLAB27.
No special preparation is needed for this test.
No, fasting is not required for the HLAB27. You can eat and drink normally unless your doctor has advised otherwise.
The HLAB27 is done on a blood sample.
For a blood-based test, a small blood sample is collected by a trained healthcare professional, usually from a vein in the arm. The collection normally takes only a few minutes; mild temporary discomfort or bruising can occur at the puncture site.
Reports for the HLAB27 are usually ready within 24 hours of sample collection. You receive them on WhatsApp and email.
The HLAB27 costs Rs 830 at HWP Diagnostic (MRP Rs 1100). Home sample collection is free.
Your report should be read using the reference interval, unit and method shown by the performing laboratory. A result outside a reference interval does not automatically establish a diagnosis, and a result inside the interval does not rule out every health problem. Clinical interpretation depends on symptoms, history and other findings.
If the HLAB27 is reported as high, low, positive, negative or otherwise outside the laboratory's stated interval, the meaning depends on the specific test and the reason it was ordered. Your clinician may consider repeat testing, related investigations or other clinical information before deciding what the result means.
The HLAB27 can provide important information, but laboratory results are generally interpreted together with symptoms, medical history, examination and other investigations. A single result should not be treated as a diagnosis without clinical context.
Some medicines, supplements, food, exercise and other pre-test factors can affect particular laboratory results. Tell the healthcare professional about medicines and supplements you take, and do not stop prescribed medicines unless your clinician tells you to.
Yes. Free home sample collection for the HLAB27 is available across Malad, Kandivali, Borivali and Goregaon in Mumbai. You can also visit our Malad West lab, open 24x7.